Shares of Cadila Healthcare (down 4.05 per cent), Glenmark Pharmaceuticals (down 3.68 per cent), Biocon (down 2.73 per cent) and Sun Pharmaceutical Industries (down 2.02 per cent), were among the worst performers.
Piramal Enterprises (down 1.49 per cent), Lupin (down 0.87 per cent) and Dr. Reddy's Laboratories (down 0.61 per cent) too were among the top losers in the index.
Benchmark NSE Nifty50 index was down 116.10 points at 10,108.65 while BSE Sensex was down 383.7 points at 33,650.26 at that time.
Among the 50 stocks in the Nifty index, 6 were trading in the green, while 44 were in the red.
Shares of YES Bank, L&T Fin Holding, SBI, Idea Cellular, Wipro, ICICI Bank, RIL, HPCL and Ashok Leyland were among the most traded securities on the National Stock Exchange.