Uber Technologies Inc.’s top deal maker, Cameron Poetzscher, has resigned from the company, a departure that comes less than a month after a Wall Street Journal article revealed allegations of prior sexual misconduct in the office.

Mr. Poetzscher, the corporate development head, was a trusted adviser to Chief Executive Dara Khosrowshahi and oversaw Uber’s biggest deals, like the $7.7 billion investment from SoftBank Group Corp. and the sale of its Southeast Asia operations.