Twenty people were killed when a limousine crashed into another vehicle and bystanders outside a restaurant in upstate New York.

New York State Police say the deadly collision happened just before 2pm on Saturday in the small town of Schoharie, 40 miles west of Albany, where emergency crews worked well into the night.

According to media reports, 18 of the 20 victims were inside the limousine, which The New York Times says was carrying members of a wedding party.

Emergency responders from several agencies arrived at the Apple Barrel Country Store to help.

The National Transportation Safety Board is looking into the crash with investigators re-creating the scene.