Police search for man missing after Sydney CBD car crash

Police are searching for a man who disappeared after a car crash in Sydney's CBD.

Mark Rust, 31, has not been seen after fleeing the scene of a car crash on Kent Street about 8am on Wednesday, police say.

His family and police hold serious concerns for him, as they have not heard from him since the crash and he suffers from a medical condition.

While the car crash was minor, a police spokeswoman said it was unclear if Mr Rust had been injured in the incident.

Mark is described as being of Caucasian appearance, between 170 and 180 centimetres tall with a medium build, brown hair and brown eyes.

He was last seen wearing a black T-shirt with a logo on the front and light pants. He was also wearing hearing aids.

Anyone with information about Mr Rust's whereabouts or anyone who spots him is urged to contact Crime Stoppers.