David Davis, U.K. Minister in Charge of Brexit Negotiations, Resigns

Resignation follows cabinet agreement Friday over proposal for future EU relations

LONDON—David Davis, the minister in charge of negotiating Britain’s exit from the European Union, resigned unexpectedly Sunday night, according to someone familiar with the decision, likely heralding a further period of turmoil for the trouble-prone government of Prime Minister Theresa May.

The resignation by a prominent minister who campaigned for Britain to leave the EU follows a cabinet meeting on Friday in which a plan for Britain’s future relationship was finally hammered out, 25 months after a referendum vote to leave...