• New York Yankees' Giancarlo Stanton hits a walk-off two-run home run during the ninth inning of a baseball game against the Seattle Mariners at Yankee Stadium Wednesday, June 20, 2018, in New York. The Yankees defeated the Mariners 7-5. (AP Photo/Seth Wenig) Photo: Seth Wenig / AP
Photo: Seth Wenig
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New York Yankees' Giancarlo Stanton hits a walk-off two-run home run during the ninth inning of a baseball game against the Seattle Mariners at Yankee Stadium Wednesday, June 20, 2018, in New York. The Yankees defeated the Mariners 7-5. (AP Photo/Seth Wenig) less
New York Yankees' Giancarlo Stanton hits a walk-off two-run home run during the ninth inning of a baseball game against the Seattle Mariners at Yankee Stadium Wednesday, June 20, 2018, in New York. The Yankees ... more
Photo: Seth Wenig
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NEW YORK, NY - JUNE 20: Aaron Judge #99 of the New York Yankees hits a double in the first inning against the Seattle Mariners at Yankee Stadium on June 20, 2018 in the Bronx borough of New York City. (Photo by Mike Stobe/Getty Images) less
NEW YORK, NY - JUNE 20: Aaron Judge #99 of the New York Yankees hits a double in the first inning against the Seattle Mariners at Yankee Stadium on June 20, 2018 in the Bronx borough of New York City. (Photo ... more
Photo: Mike Stobe
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NEW YORK, NY - JUNE 20: Jonathan Loaisiga #38 of the New York Yankees pitches in the first inning against the Seattle Mariners at Yankee Stadium on June 20, 2018 in the Bronx borough of New York City. (Photo by Mike Stobe/Getty Images) less
NEW YORK, NY - JUNE 20: Jonathan Loaisiga #38 of the New York Yankees pitches in the first inning against the Seattle Mariners at Yankee Stadium on June 20, 2018 in the Bronx borough of New York City. (Photo ... more
Photo: Mike Stobe
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New York Yankees starting pitcher Jonathan Loaisiga throws during the first inning of a baseball game against the Seattle Mariners at Yankee Stadium Wednesday, June 20, 2018, in New York. (AP Photo/Seth Wenig)
New York Yankees starting pitcher Jonathan Loaisiga throws during the first inning of a baseball game against the Seattle Mariners at Yankee Stadium Wednesday, June 20, 2018, in New York. (AP Photo/Seth Wenig)
Photo: Seth Wenig
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NEW YORK, NY - JUNE 20: Gary Sanchez #24 of the New York Yankees connects on a 2-run home run in the bottom of the eighth inning against the Seattle Mariners at Yankee Stadium on June 20, 2018 in the Bronx borough of New York City. (Photo by Mike Stobe/Getty Images) less
NEW YORK, NY - JUNE 20: Gary Sanchez #24 of the New York Yankees connects on a 2-run home run in the bottom of the eighth inning against the Seattle Mariners at Yankee Stadium on June 20, 2018 in the Bronx ... more
Photo: Mike Stobe
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New York

Giancarlo Stanton lined a two-run homer with two outs in the bottom of the ninth inning, and the New York Yankees erased a five-run deficit to beat the Seattle Mariners 7-5 on Wednesday night.

Gary Sanchez tied the score with a two-run homer in the eighth, and the Yankees went on to complete their largest comeback victory of the season.

Didi Gregorius singled with two outs in the ninth and Stanton hammered an 0-2 breaking ball from reliever Ryan Cook (1-1). The slugger knew it was gone the moment he connected, and he took a little jump at home plate and pumped his arm before tossing his bat aside and circling the bases.

The drive traveled a projected 453 feet to left-center for Stanton's first walk-off homer with the Yankees — his previous one came in April 2014 for the Marlins (also vs. Seattle). He was mobbed by teammates and doused as he crossed the plate, throwing his helmet into the air and smiling from ear to ear.

"I'm not worried about my personal signature moment," Stanton said. "Just happy to be able to get it for us."

New York is a season-high 27 games above .500 with the majors' best record at 49-22. The Yankees have won nine of 11 against Seattle (46-28) and will try for a three-game series sweep Thursday afternoon.

"Until the game is over, we've got a chance. It showed tonight," Stanton said.

Aroldis Chapman (3-0) pitched a perfect inning for the win.

The Mariners have lost three straight for the first time since April 17-19 against the Astros.

Seattle starter Felix Hernandez lasted five innings and 95 pitches. He was charged with two runs, one earned, and six hits.

Sanchez drove Alex Colome's cutter 439 feet off the back wall of the left-center bullpen, tying the score at 5.

Dee Gordon had two RBIs for the Mariners. Denard Span and Ryon Healy each drove home a run in the fifth, extending Seattle's advantage to 5-0.

Yankees rookie Jonathan Loaisiga, making his second major league start in place of injured Masahiro Tanaka, allowed three runs on six hits and two walks in 32/3 innings.

New York broke through in the fifth with two outs and runners on first and second. Aaron Judge's broken-bat single to left scored Miguel Andujar. Aaron Hicks came home when Span bobbled the ball.

Gregorius' sacrifice fly in the seventh made it 5-3.

Note: Yankees outfielder Brett Gardner (swollen right knee) ran and took batting practice before the game. He has not played since Saturday.