The Federal Reserve raised rates by 25 basis points and signaled two additional rate hikes later in the year. Wednesday's interest rate hike pushed up the funds rate target to 1.75 percent to 2 percent. The central bank's first rate hike this year took place in March.
U.S. stocks ended lower after the Fed raised interest rates, with the Dow Jones industrial average declining 0.47 percent, or 119.53 points, to close at 25,201.20.
U.S. Treasury yields rose on the back of the Fed's move, with the yield on the benchmark 10-year note crossing the 3 percent level, before later receding a bit. The two-year Treasury note yield, meanwhile, hit its highest level since 2008 in the last session.
The dollar index, which tracks the greenback against a basket of currencies, rose as high as 94.028 on Wednesday, before easing to last trade at 93.482.
Trade tensions, which had recently yielded some of the spotlight to nuclear negotiations, could return to the fore. U.S. President Donald Trump is expected to meet with members of his administration to make a decision on whether or not to activate billions in tariffs on Chinese imports, Reuters reported, citing a source.