Elucidating the natural history and underlying genetic causes of Parkinson's disease and related Lewy body disorders is crucial in guiding our development of therapeutic intervention strategies. Approximately 15% of patients with Parkinson's disease report a family history of the disease, and studies have identified or nominated a small number of disease-associated genes from multi-incident families. However, these genes account for only 5–10% of familial cases of Parkinson's disease. As such, many more rare genetic forms probably exist.
Original Article: [Comment] A novel link between trafficking and Lewy body disorders