Mike Pompeo, the US secretary of state, is expected to call on European countries to help ramp up economic pressure on Iran as he outlines America's ‘Plan B’ to the nuclear deal.
Delivering his first major foreign policy speech since taking the job, Mr Pompeo will double down on the United States’ decision to quit the agreement earlier this month.
He is expected to frame the 2015 deal as allowing Iran to increase its malign influence across the Middle East on the back of funding from renewed trade with the West.
Mr Pompeo is also expected to urge other nations to join America in reimposing economic sanctions on the regime in a bid to bring it back to the negotiating table.
The speech comes with America at loggerheads with its closest allies after Donald Trump finally made good his threat to pull the US out of the Iran nuclear deal.
The agreement, struck by his predecessor Barack Obama, agreed to waive economic sanctions in turn for Iran giving up much of its nuclear programme.
Other signatories of the deal - Britain, France, Germany, the European Union, China, Russia and Iran - have said they will try to keep the agreement alive.
However its future remains in the balance, with Iran saying it will only keep to the agreement if the economic benefits gained from the agreement remain in placed.
American allies have been clamouring for the Trump administration to explain its ‘Plan B’ approach to Iran after unilaterally quitting the deal.
Mr Trump, the US President, and his officials have called for a wider deal that addresses Iran’s ballistic missile programme and regional adventurism as well as its nuclear ambitions.
However it remains unclear how they hope to strike the new deal, given it would need Iran to come back to the negotiating table.
Speaking in Washington on Monday, Mr Pompeo is expected to repeat Mr Trump’s view that ramping up the economic pressure on the regime will convince it to enter new talks.
A senior State Department official outlined the message in a comment to the US political website Axios.
"We are welcoming ALL nations to join us in pushing back against Iran — our sanctions regime and our broader efforts welcome the participation of all countries,” the official was quoted as saying.
“Certainly includes our allies in the Arab world, our European and Asian allies. Iran's threats extend globally, the response to their malign behavior should match that."
Another source with knowledge of the speech was quoted saying Mr Pompeo would warn Iran “advanced its march across the Middle East” with “wealth created by the West” thanks to the nuclear agreement.
Much of the effectiveness of the Trump administration’s reimposition of sanctions depends on European businesses cutting economic ties with Iran.
Firms in the EU have taken much more advantage of the 2015 waiving of sanctions to sign contracts increasing business in Iran than those in America.
The EU exported over €10.8 billion (£9.4 billion) worth of goods to Iran in 2017, half of which was made up by machinery and transport. That is up from €6.5 billion (£5.7 billion) in 2015.
Senior Trump administration officials have threatened to impose ‘secondary sanctions’ on European businesses if they refuse to cancel their contracts.
In return the EU has moved to reimpose a “blocking statue” originally meant to circumvent a the US embargo against Cuba in the 1990s that would protect European businesses.