New South Wales hopeful Curtis Scott looks to have blown any chance of being named for the State of Origin opener after the Melbourne centre became the first NRL player to be sent off since 2015.

Scott is facing a lengthy ban after he was marched in the 52nd minute of Melbourne's 4-24 loss to Manly at AAMI Park after he threw a flurry of punches at Manly's Dylan Walker, leaving him with a suspected fractured eye socket.

The Sea Eagles five-eighth and hooker Apisai Koroisau were also sin-binned for their part in the brawl.

As well as showing he can handle the big stage as a premiership centre last season, the tough 20-year-old has formed a threatening left-edge combination NSW certainty Josh Addo-Carr.

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With incoming NSW coach Brad Fittler planning a clean-out of the Blues Origin team, Scott's timing couldn't have been worse.

Storm coach Craig Bellamy was disappointed Scott reacted so poorly to the niggle from Walker.

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Manly's Dylan Walker had immediate swelling to his left eye following the blows from Storm star Curtis Scott.

"He needs to learn from this," Bellamy said.

"One thing you like about him is that he's really competitive and that's the first time he's done that but he will learn from that because it's going to be fairly costly to us and to him as well."

Meanwhile, Melbourne have reportedly already contacted the NRL over the two Manly players allegedly returning almost two minutes early from the sin bin.

The Storm were seething after the pair returned before 10 minutes had lapsed.

Fox League reported that the Manly players had returned to the field 1min 41 seconds early.

They also said Storm chief executive Dave Donaghy had phoned NRL boss Todd Greenberg and head of football Brian Canavan before the end of play about the stuff-up.

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Storm centre Curtis Scott has become the first NRL player to be sent off since 2015.

While both coaches said they weren't clear on what happened, Storm general manager of football Frank Ponissi confirmed the error.

But Ponissi said that given the 24-4 scoreline, it was unlikely they would take it further.

"It was obviously an error and he made a mistake but I personally don't want to dwell on it," Ponissi said.

"He made a mistake and, hopefully, it doesn't happen again."

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Dylan Walker protests being sent to the sin bin during Manly's 24-4 upset win over the Storm on Saturday night.

The NRL issued a statement post-match saying it would investigate:

"The NRL will conduct a full review of the timing of the dismissals and the process.

"The responsibility of the timing for sin bins is held by the clubs, although in this instance, it appears there were no club supplied sin bin operators present at the venue."

 - AAP