INDICATION: Tuberculosis
Mouse studies suggest a fusion protein-based vaccine plus a STING-activating cyclic dinucleotide (CDN) adjuvant could help prevent tuberculosis (TB). The fusion protein consists of five Mycobacterium tuberculosis antigens: fbpB, esxA, hrp1, rpfD and Rv1733c. In a mouse challenge model of TB, subcutaneous immunization with the fusion protein plus STING-activating cyclic diguanylate (CDG) decreased colony-forming units (CFUs)...