INDICATION: Renal failure; heart failure; liver failure
Mouse studies suggest inhibiting YY1 or its co-repressor FKBP12 could help treat chronic renal, heart and liver failure. In a mouse model of urethral obstruction-induced chronic renal failure, a tool compound FKBP12 inhibitor or guanidine dendrimer-linked morpholino oligomers targeting FKBP12 or YY1 decreased...