Diabetes, Obesity, and Other Insulin-Related Diseases

10:12 EDT 26 Apr 2018 | NIH

This technology claims methods for treating diseases or conditions associated with insulin resistance using the small molecule epoxy-guaiane derivative englerin A and related compounds. The compounds are claimed separately in a related NIH technology.

The inventors have shown that englerin A, a compound originally isolated from the Phyllanthus plant and previously identified as an anti-cancer agent, can also be used to treat insulin resistance. Insulin resistance is associated with reduced gene expression and production of heat shock protein 70 (HSP70). Using a mouse with tumor model, the inventors discovered that administration of englerin A decreases blood glucose levels by activating transcription of HSF1, thereby increasing the expression and secretion of HSP70. Thus, englerin A and related compounds represent potential drugs for the treatment of a variety of conditions associated with insulin resistance.

IC: 
NCI
NIH Ref. No.: 
E-042-2012
Advantages: 
  • Use of small-molecule compounds targeting HSF1 represents a novel approach to the treatment of type 2 diabetes and other conditions caused by insulin resistance.
Applications: 
  • Treatment of diseases or conditions associated with insulin resistance, such as type 2 diabetes, obesity, inflammation, metabolic syndrome, polycystic ovary disease, arteriosclerosis, non-alcoholic fatty liver disease, reproductive abnormality of a female, and growth abnormality.
Development Status: 

Discovery (Lead Identification)

Updated On: 
Apr 24, 2018
Provider Classifications: 
Publications: 
Patent Application: 
61/584,526
PCT/US13/20051
Patent Authority: 
US
Foreign Filed
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
Inventor Lab URL: 
https://ccr.cancer.gov/urologic-oncology-branch/leonard-m-neckers
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Email: 
John.Hewes@nih.gov
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Therapeutics
DTDT Description: 
Therapeutics
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-042-2012
Inventor First Name: 
Leonard
Inventor Last Name: 
Neckers

Original Article: Diabetes, Obesity, and Other Insulin-Related Diseases

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