Third Time Unlucky for Takeda and Shire

Rejected offers to buy Shire highlight Takeda’s limited flexibility to get deal done

The latest big deal proposed in the pharmaceuticals industry isn’t likely to happen.

Takeda Pharmaceutical recently approached Dublin-based Shire PLC. It emerged Thursday that the Japanese drug giant has made three separate offers to acquire Shire, the last of which amounted to about $60 billion in stock and cash, but Shire said it has rejected all three offers.

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