In animal models, disease recapitulation is the guiding principle. Scientists spend considerable time and effort trying to reproduce—as closely as possible—the exact molecular and physiological conditions associated with various diseases states. To that end, a new study from investigators at the Seve Ballesteros Foundation-CNIO Brain Tumor Group at the Spanish National Cancer Research Centre (CNIO) describes an extremely powerful and versatile mouse model that will improve cancer research and accelerate preclinical testing of novel targeted therapies. Findings from the new study were published today in Nature Communications , in an article entitled “ Somatic Genome Editing with the RCAS-TVA-CRISPR-Cas9 System for Precision Tumor Modeling .” "A current high priority in cancer research is to functionally validate candidate genetic alterations that are relevant for cancer progression and treatment response,” the authors stated. “In order to do so, it is essential to develop flexible models that can speed up the ...
Original Article: CRISPR Combines with Gene Delivery System to Create Brain Tumor Model