In a Nature Communications study, a Harvard team developed extracellular vesicles that can deliver a variety of macromolecular cargo inside target cells or tissues, paving the way for therapeutics against traditionally intractable intracellular targets.
Previously, a group led by Quan Lu, an associate professor of environmental genetics and pathophysiology at Harvard T. H. Chan School of Public Health, showed that arrestin domain containing 1 (ARRDC1) catalyzes the budding of vesicles that can contain more than 100 functional proteins, including NOTCH.
While NOTCH signaling was thought to occur only between neighboring cells, Lu and colleagues showed in a 2012 Proceedings of the...