Scientists report that they have found new genetic mutations that promote the survival of cancer cells. Their study also provided a clearer understanding of how some cancer cells are able to resist treatment, the researchers added. The findings (“ Novel putative drivers revealed by targeted exome sequencing of advanced solid tumors ”) are published in PLOS ONE. “ Next generation sequencing (NGS) is becoming increasingly integrated into oncological practice and clinical research. NGS methods have also provided evidence for clonal evolution of cancers during disease progression and treatment. The number of variants associated with response to specific therapeutic agents keeps increasing. However, the identification of novel driver mutations as opposed to passenger (phenotypically silent or clinically irrelevant) mutations remains a major challenge,” write the investigators. “We conducted targeted exome sequencing of advanced solid tumors from 44 pre-treated patients with solid tumors including breast, colorectal and lung ...
Original Article: Advanced Cancers Display New Possible Driver Mutations Never Described Before
NEXT ARTICLE