Researchers from the by Dana-Farber Cancer Institute say it may be possible to stop tumors from recurring and to eradicate metastatic growths by implanting a gel containing immunotherapy during surgical removal of a tumor. The team published its study (“ Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases ”) in Science Translational Medicine . “Cancer immunotherapy can confer durable benefit, but the percentage of patients who respond to this approach remains modest,” the researchers wrote. “The ability to concentrate immunostimulatory compounds at the site of disease can overcome local immune tolerance and reduce systemic toxicity. “Surgical resection of tumors may improve the efficacy of immunotherapy by removing the concentrated immunosuppressive microenvironment; however, it also removes tumor-specific leukocytes as well as tumor antigens that may be important to establishing antitumor immunity. Moreover, surgery produces a transient immunosuppressive state associated with wound healing that has ...
Original Article: Novel Immunotherapeutic Approach Prevents Tumors from Reoccurring
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