Liverpool and City are the only Premier League representatives left in the Champions League after Tottenham, Chelsea and Manchester United crashed out in the last round.
And the two English teams will face off in the quarter-finals, meaning it is guaranteed there will be one Premier League side in the last four.
There promises to be plenty of goals in this game as there have been 12 goals in the two league fixtures between them this season.
Both sides have won on their home grounds with City claiming a comfortable 5-0 victory earlier in the season before Liverpool handed Pep Guardiola his first defeat of the season in January.
Teams are often keen on having the second leg at home due to the away goals rule and City hold that advantage this time around.
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It's an advantage for them having the second leg at home but then again their ground doesn't generate an atmosphere
However, Aldridge believes the Premier League leaders will not know how to cope with a Champions League night at Anfield.
“We didn't want to get Manchester City in the quarter-final draw of the Champions League and they certainly didn't want to get us,” Aldridge told the Liverpool Echo.
“But those are the cards we've been dealt and we have to get on with it. It's a 50/50 call.
“Possibly, it's an advantage for them having the second leg at home but then again their ground doesn't generate an atmosphere.
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“We have to make the first leg count. I've been lucky enough to experience some very special European nights at Anfield over the years where the place is rocking and we have to add Man City to the list.
“Some of their players will shake when they feel the atmosphere we create. They won't have heard anything quite like it.
“There's no reason for us to fear City. I know we lost heavily in the league at their place but until the Sadio Mane red card there was very little between the teams.”