Okayama University Research: Iron Removal as a Potential Cancer Therapy

05:47 EDT 21 Mar 2018 | Lab Bulletin

Iron chelators Deferasirox and Deferoxamine (DFO) suppress the expression of stemness marker.Researchers at Okayama University report in Oncotarget a promising method for targeting cancer stem cells that cause tumor growth and cancer relapse. The approach involves administering molecules that capture iron, an overload of which is known to be a potential cause of cancer. Cancer stem cells (CSCs) are similar to normal stem cells in that they can differentiate — become cells of a specialized type.  CSCs are resistant to radio- and chemotherapy and are believed to play an important role in metastasis and...

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