Henrikh Mkhitaryan scored his first Arsenal goal as the London club rebounded from four successive losses with a 2-0 win at AC Milan in the first leg of the Europa League last 16 on Thursday.

There was another surprise in Germany where two goals from Valon Berisha led Salzburg to a 2-1 victory at Borussia Dortmund.

Atletico Madrid recorded a comfortable 3-0 home win over Lokomotiv Moscow while CSKA Moscow were beaten 1-0 in Russia by Lyon.

Fredy Montero's two goals guided Sporting past Viktoria Plzen 2-0 and Leipzig, who knocked out Serie A leaders Napoli in the round of 32, defeated Zenit 2-1.

Lazio were held to a 2-2 home draw by Dynamo Kiev while Marseille struck in the first minute on the way to a 3-1 victory over Athletic Bilbao.

A minute's silence was observed at every match in honor of Davide Astori, the Italy and Fiorentina player who died last week at the age of 31.

MILAN MISERY

In a tussle of two heavyweights with proud histories, Arsenal went ahead after 15 minutes when Mkhitaryan, signed from Manchester United in January, saw his right-foot shot deflect into the net off Milan captain Leonardo Bonucci.

Mkhitaryan also hit the crossbar towards the end of the first half.

Bonucci almost leveled for Milan two minutes before the interval when he rose in the penalty area to head a corner narrowly wide.

Mesut Ozil then laid on the second goal in first-half stoppage time for Aaron Ramsey, who went round goalkeeper Gianluigi Donnarumma to give his team a healthy advantage to take into the second leg at the Emirates Stadium next Thursday.

"Our best away performance for a long time," Ozil tweeted.

ATLETICO CRUISE

Saul Niguez fired a spectacular shot from 25 meters to put Atletico in front against Lokomotiv in the 22nd minute before Diego Costa added his sixth goal in 13 matches since rejoining the club from Chelsea.

Costa pounced to score after Antoine Griezmann's goalbound effort was saved before captain Koke made it 3-0 in the final minute.

Atletico have reached two Champions League finals since winning the Europa League in 2012.

EARLY STRIKES

Marseille didn't waste any time against Bilbao as Lucas Ocampos netted inside the first minute after collecting a pass from Florian Thauvin.

Captain Dimitri Payet made it 2-0 after 14 minutes. Aritz Aduriz pulled one back for Bilbao from the penalty spot in injury time before Ocampos struck again in the second half after Payet had set him up.

OTHER GAMES

Berisha was twice on target early in the second half, his opener coming from the penalty spot, to put Salzburg on top before Andre Schurrle pulled one back for Dortmund.

Lyon were indebted to a 68th-minute header from Marcelo as the French team triumphed at CSKA.

Leipzig squandered numerous chances against Zenit before Armindo Bruma scored in the second half after Timo Werner’s brilliant backheel assist.

Werner lobbed in a second over goalkeeper Andrei Lunev but Domenico Criscito got one back for Zenit from a free kick.

After a hat-trick in the last round, Ciro Immobile equalized for Lazio with his 32nd goal of the season two minutes after Viktor Tsygankov had put Kiev 1-0 up.

Felipe Anderson made it 2-1 to Lazio before substitute Junior Moraes leveled 11 minutes from time.