Cape Town - Wales have suffered a blow ahead of their Six Nations game against England at Twickenham on Saturday after Leigh Halfpenny was ruled out.

Halfpenny is sidelined with a foot infection and is replaced in the starting XV by Gareth Anscombe, with Owen Watkin coming onto the bench.

Rhys Patchell is expected to take over the goal-kicking from his Scarlets team-mate, who scored 24 points last weekend against Scotland.

Teams:

England

15 Mike Brown, 14 Anthony Watson, 13 Jonathan Joseph, 12 Owen Farrell, 11 Jonny May, 10 George Ford, 9 Danny Care, 8 Sam Simmonds, 7 Chris Robshaw, 6 Courtney Lawes, 5 Maro Itoje, 4 Joe Launchbury, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Mako Vunipola

Substitutes: 16 Jamie George, 17 Alec Hepburn, 18 Harry Williams, 19 George Kruis, 20 Sam Underhill, 21 Richard Wigglesworth, 22 Ben Te'o, 23 Jack Nowell

Wales

15 Gareth Anscombe, 14 Josh Adams, 13 Scott Williams, 12 Hadleigh Parkes, 11 Steff Evans, 10 Rhys Patchell, 9 Gareth Davies, 8 Ross Moriarty, 7 Josh Navidi, 6 Aaron Shingler, 5 Alun Wyn Jones (captain), 4 Cory Hill, 3 Samson Lee, 2 Ken Owens, 1 Rob Evans

Substitutes: 16 Elliot Dee, 17 Wyn Jones, 18 Tomas Francis, 19 Bradley Davies, 20 Justin Tipuric, 21 Aled Davies, 22 Owen Watkin, 23 George North