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Wales had their first two tries inside 11 minutes against Scotland although it took them until the 72nd minute to secure the bonus point for a fourth, before Peter Horne ensured the away side did not leave without scoring a single point.
England meanwhile were a little more leaky in defence, twice allowing Italy to score in Rome, but ran in seven tries of their own as Sam Simmonds marked his Six Nations debut with a second-half double.
It means England hold top spot in the table on points difference alone - but will face an entirely different challenge when Wales arrive with an upset on their mind.
Wales’ visit to Twickenham will be the second game of the day, kicking off at 4.45pm on Saturday February 10.
The Six Nations coverage for 2018 has been split between ITV and the BBC once again.
ITV will show all of England’s home games as well as four others while the BBC will retain all of the other eight matches including England’s trips to Edinburgh and Paris.
That means England vs Wales will be live on ITV, with coverage starting at 4.20pm, after conclusion of reaction to Ireland vs Italy, also on ITV on Saturday.
Six Nations Rugby
Since both ITV and BBC are terrestrial and free-to-air, every game of the Six Nations will be shown live online for free.
Viewers simply need to hold a valid TV licence and may be required to sign in on the ITV website in order to watch England vs Wales.
An injury to Ben Youngs, who faces four months out with knee ligament damage, means Danny Care is likely to start at scrum-half on Saturday.
Other changes are possible - Ben Te’o was a surprise starter at 13 and could revert to the bench with Jonathan Joseph coming in, while Nathan Hughes has made a strong recovery from his knee injury and could figure after a recall to the training squad.
Wales are unchanged after a 34-7 win over Scotland.
Starting XV: Leigh Halfpenny; Josh Adams, Scott Williams, Hadleigh Parkes, Steff Evans; Rhys Patchell, Gareth Davies; Rob Evans, Ken Owens, Samson Lee, Cory Hill, Alun Wyn Jones, Aaron Shingler, Josh Navidi, Ross Moriarty.
Replacements: Elliot Dee, Wyn Jones, Tomas Francis, Bradley Davies, Justin Tipuric, Aled Davies, Gareth Anscombe, Owen Watkin.
