Fellaini came off shortly after being brought on in the midweek defeat at Tottenham and faces a spell on the sidelines with a knee injury.
Defender Eric Bailly and striker Zlatan Ibrahimovic remain absent, while utility man Daley Blind has been out with an ankle issue recently.
But January signing Alexis Sanchez, who failed to impress away at Tottenham is in line to make his home debut for Manchester United.
Meanwhile, visitors Huddersfield will be without Danny Williams for a second game in succession when they travel to Old Trafford.
GETTY
GETTY
Williams missed the midweek defeat to Liverpool due to the dead leg he suffered during the FA Cup tie against Birmingham and he has not recovered in time.
Chris Lowe (groin) is also ruled out as the Terriers try to end a four-game losing streak which has left them just a point above the relegation places.
Loan signing Terence Kongolo was taken to hospital after feeling ill following the Liverpool game, but he has been given the all-clear.
Manchester United provisional squad: De Gea, Romero, Pereira, Valencia, Darmian, Jones, Lindelof, Smalling, Rojo, Shaw, Young, Matic, Carrick, McTominay, Herrera, Pogba, Lingard, Mata, Martial, Rashford, Sanchez, Lukaku.
Huddersfield provisional squad: Lossl, Coleman, Malone, Hadergjonaj, Schindler, Jorgensen, Smith, Kongolo, Hogg, Mooy, Pritchard, Ince, Van La Parra, Depoitre, Quaner, Billing, Sabiri, Mounie.