A central task for surgical pathologists diagnosing tumours is to reliably assess tumour aggressiveness from morphologic features. This tumour grade guides clinical therapy planning, and specific grading systems exist for all major tumour types. Typical components of grading systems are tissue architecture, degree of resemblance to the respective benign tissue, mitotic activity, necrosis, and aberrances in nuclear morphology (ie, nuclear pleomorphism, variations in size, nucleolar prominence, and chromatin distribution).
Original Article: [Comment] Next-generation nuclear morphology to grade solid tumours
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