Caleb Wood had 17 of his 22 points during the second half and overtime to help Pennsylvania beat Brown 95-90 on Friday night.
The Quakers (14-6, 4-0 Ivy League) closed on a 6-0 run over the final 1:11 of overtime.
The Bears (9-9, 2-3) trailed 93-90 when Zach Hunsaker missed a 3-point attempt with five seconds left. Wood made 1 of 2 free throws with four seconds left and Max Rothschild added another free throw in the final second.
Penn also scored the final six points of regulation, all on free throws, while Brown missed three field-goal attempts over the final three minutes of the period.
Antonio Woods added 21 points, Ryan Betley had 16, Rothschild 15 and Darnell Foreman 12 for Penn.
Desmond Cambridge had 29 points to lead Brown, the second-highest output of his freshman season. Brandon Anderson added 18 points, Hunsaker scored 14 and Tamenang Choh 12.
Brown made seven more field goals than Penn (35-28), but the Quakers had 44 foul shots and made 30 compared to the Bears who made 12 of 19 from the foul line.
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