THOUSAND OAKS, Calif. (AP) — Amgen Inc. (AMGN) on Thursday reported a fourth-quarter loss of $4.26 billion, after reporting a profit in the same period a year earlier.

On a per-share basis, the Thousand Oaks, California-based company said it had a loss of $5.89. Earnings, adjusted for pretax expenses and non-recurring costs, were $2.89 per share.

The results fell short of Wall Street expectations. The average estimate of 11 analysts surveyed by Zacks Investment Research was for earnings of $3.04 per share.

The world's largest biotech drugmaker posted revenue of $5.8 billion in the period, which also fell short of Street forecasts. Eight analysts surveyed by Zacks expected $5.86 billion.

Amgen expects full-year earnings in the range of $12.60 to $13.70 per share, with revenue in the range of $21.8 billion to $22.8 billion.

Amgen shares have risen slightly more than 6 percent since the beginning of the year, while the Standard & Poor's 500 index has increased slightly more than 5 percent. In the final minutes of trading on Thursday, shares hit $185.08, a climb of 16 percent in the last 12 months.

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This story was generated by Automated Insights (http://automatedinsights.com/ap) using data from Zacks Investment Research. Access a Zacks stock report on AMGN at https://www.zacks.com/ap/AMGN

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