The company said its plans for the new self-styled fulfilment centre at Rugby would open up a variety of positions including engineers and HR and IT specialists.
It currently operates a network of 16 fulfilment centres - sprawling warehouses in the main which handle orders on behalf of customers and within its marketplace.
They have attracted criticism in the past amid allegations of tough working conditions, including exhausting performance targets for those picking items for delivery.
Amazon, which has rejected any suggestion of poor practice, said the work on offer in Rugby was attractive.
Its director of UK customer fulfilment, Stefano Perego, said: "We are delighted to expand our operations in the Midlands where we already have a dedicated workforce of more than 2,500 people at fulfilment centres in Rugeley, Coalville and Daventry,"
"We are thrilled to begin recruitment for 400 new permanent roles in Rugby with competitive wages and comprehensive benefits starting on day one."
Amazon said of its pay package: "The pay rate for permanent Amazon employees increases over their first two years of employment, when all employees earn £8.35 an hour and above.
"All permanent Amazon fulfilment centre employees are given stock grants, which over the last five years were on average equal to £1,000 or more per year per person.
"Employees are offered a comprehensive benefits package, including private medical insurance, life assurance, income protection, subsidised meals and an employee discount, which combined are worth more than £700 annually, as well as a company pension plan."
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