The latest news on which players are out and who is on the way back from injury for all six countries ahead of the 2018 Six Nations, which kicks off on February 3.
England
Unknown
Chris Robshaw - Yet to train fully due to a back injury but is out in Portugal with the England squad going through a recovery programme in the pool.
Mike Brown - Suffering form blurred vision after a head knock, putting his participation against Italy in doubt.
Short-term
Beno Obano - Set to miss the opening fixture with Italy due to a knee injury.
Charlie Ewels - Out for a further two-three weeks with a hamstring issue according to the Bath Chronicle.
Jack Nowell - Named in England's squad for the Six Nations opener against Italy despite a recent ankle injury.
Matt Mullan - Due back at the end of January following a rib injury according to the Coventry Telegraph.
Piers Francis - Currently in the concussion protocol...