Manchester United have won all three of their previous FA Cup ties against Yeovil by an aggregate score of 13-0.
Yeovil currently sit just above the relegation zone in League Two and ex-Arsenal man Alexis Sanchez could make his debut against the Glovers after completing his move earlier this week.
Since beating Sunderland in January 1949, Yeovil have lost each of their last nine FA Cup games against top-flight sides, failing to score on seven occasions.
United will be the overwhelming favourites going into this one but anything can happen in the cup and Arsenal's embarrassing exit to Nottingham Forest was a reminder of that.
Jose Mourinho will likely field a fairly strong squad for this fixture as United will not play again until next Wednesday when they face Spurs.
Which TV channel is Yeovil Town vs Manchester United on?
Yeovil Town vs Manchester United will be shown live on BBC One from 7:30pm on Friday 26 January.
Kick-off from Huish Park is at 7:55pm.
You will be able to follow all the action on our live blog as always.
Team news for Yeovil Town vs Manchester United
United's new no.7 Alexis Sanchez is eligible and Mourinho could choose to field him from the start or bring him on from the bench as the Chilean is in the squad.
Ahead of the press conference, Antonio Valencia posted a video of Eric Bailly that shows the defender is back running, although it's still too soon for him to be in the squad.
Odds for Yeovil Town vs Manchester United (Sky Bet)
Yeovil Town - 18/1
Draw - 13/2
Man Utd - 1/7
Man Utd to win 2-0 - 5/1
Alexis Sanchez last goalscorer - 10/3
Juan Mata to score first and Man Utd to win 3-1 - 35/1
Lukaku & Lingard to score, BTTS and over 2.5 goals - 5/1
