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Novel β-chain-targeting approach for the treatment of lymphoma [PreClinical]
00:25 EST 21 Jan 2018 | 2 Minute Medicine
1. The β-chain constant region of the T cell receptor (TCR) was targeted to specifically eliminate a population of malignant T cells. 2. Engineered chimeric antigen receptor (CAR) T cells with specificity to the β-chain constant region successfully eradicated a significant proportion of malignant T cells in mice. Evidence Rating Level: 3 (Average) Study Rundown: […]
Original Article: Novel β-chain-targeting approach for the treatment of lymphoma [PreClinical]
