City will meanwhile welcome back a number of players after he shuffled his pack for the club’s EFL Cup game against Bristol City. But Gabriel Jesus, Vincent Kompany and Benjamin Mendy all remain out. City currently enjoy a 15-point lead at the top of the table.
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Post-match reaction from Pep Guardiola
His view of the game: "Congratulations to Liverpool for the victory. It was a game they started well. We recovered after 15-20 minutes. In the second half we started much, much better, the game was in our hands but the finishing was not good.
"After 10-15 minutes of the second half, it went from 1-1 to 4-1. In football you can concede one goal but you have to be stable and in that moment we were not solid enough.
"The reality is we lost the game and now we have one week to prepare for the Newcastle game."
City's unbeaten run in the Premier League is over
Post-match reaction from Liverpool's players
Alex Oxlade-Chamberlain
On ending Manchester City's unbeaten Premier League run: "It's a nice statement from us. They've been brilliant all year. We knew we had what it took to get three points today. Ultimately, it doesn't matter who we were playing, we just wanted to win today."
On scoring the opening goal of the game: "The manager keeps telling me to shoot so I gave it a go and luckily it went in."
Sadio Mane
On ending City's unbeaten run: "I think the three points was the main target. We got it and also the performance from the team was great today."
On the players' nerves when City pulled it back to 4-3 late on: "It was not easy because if you score four goals and it goes to 4-3 you're a bit scared. I think we deserved to win today."
Quotes from Sky Sports
Sadio Mane scored Liverpool's third goal of the game
Full-time - Liverpool 4-3 Manchester City
The final whistle goes and Manchester City's unbeaten run in the Premier League is over after one of the games of the season at Anfield!
90+4' - Ragnar Klavan replaces Sadio Mane for Liverpool.
GOAL! Liverpool 4-3 Manchester City (Gundogan)
90+1 - Sergio Aguero's dinked cross is expertly controlled and coolly finished by Ilkay Gundogan!
City have three minutes to keep their unbeaten Premier League run alive!
90' - We'll have a minimum of four additional minutes at the end of this one.
The moment that kick-started the onslaught: Roberto Firmino puts Liverpool 2-1 up earlier in the second half
87' - Adam Lallana replaces Mo Salah for Liverpool.
GOAL! Liverpool 4-2 Manchester City (B Silva)
84' - Ilkay Gundogan plays a neat one-two with Sergio Aguero on the edge of the box before getting a strike away. That shot is blocked but the ball rolls to Bernardo Silva, who lashes the ball past Loris Karius to give City a sliver of hope.
Game on?
83' - Gini Wijnaldum attempts to get in on the act from distance but he drags his shot a good few feet wide from around 20 yards out.
Mo Salah scores Liverpool's fourth goal
80' - James Milner replaces Emre Can for Liverpool.
77' - Kevin De Bruyne whips a superb cross in towards Nicolas Otamendi but the Argentine doesn't make good contact at the far post and the ball goes out for a goal-kick.
YELLOW CARD
73' - Fernandinho is booked for tugging back Sadio Mane.
71' - Bernardo Silva replaces Raheem Sterling for Manchester City.
Sadio Mane celebrates after scoring Liverpool's third goal of the game
YELLOW CARD
70' - Raheem Sterling is booked for a late challenge on Gini Wijnaldum.
GOAL! Liverpool 4-1 Manchester City (Salah)
68' - Unbelievable!
Ederson comes out of his box to clear a Mo Salah through pass but his clearance only goes as far as Salah, who takes a touch before lofting the ball over the City goalkeeper and in from about 40 yards!
YELLOW CARD
65' - Nicolas Otamendi is booked for a foul on Mo Salah.
He's the second player to be booked this afternoon after Roberto Firmino was cautioned for taking his shirt off in celebration after putting Liverpool 2-1 up.
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