Novel Approach Shows Which Breast Cancer Patients May Develop Incurable Metastases
King's College London researchers say they may have discovered a method to identify lymph-node positive breast cancer patients most likely to develop incurable metastases and those who are less at risk. They published their study (“Histological scoring of immune and stromal features in breast and axillary lymph nodes is prognostic for distant metastasis in lymph node-positive breast cancers”) in The Journal of Pathology: Clinical Research . “The prognostic importance of lymph node status and tumour infiltrating lymphocytes (TILs), is well established, particularly TILs in triple negative breast cancers (TNBCs). So far, few studies have interrogated changes in involved and uninvolved lymph nodes (LNs) and evaluated if their morphological patterns add valuable information for the prediction of disease progression in breast cancer. “In a cohort of 309 patients enriched for TNBCs (170/309), we histologically characterised immune and stromal features in primary tumours and associated involved and uninvolved axillary LNs ...
Original Article: Novel Approach Shows Which Breast Cancer Patients May Develop Incurable Metastases
