WATCH: Oprah's powerful Golden Globes speech that had Hollywood on their feet

Los Angeles - Oprah Winfrey accepted the lifetime achievement award at the Golden Globes by saying she hopes as the first black woman to accept the honour, it has an impact on young girls watching Sunday's ceremony.

The actress and businesswoman accepted the Cecil B. DeMille Award at Sunday's Globes ceremony and received a lengthy standing ovation, which she tried to calm down.

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She spoke about the feelings she had as a young girl watching Sidney Poitier win the best actor Academy Award in 1964. She likened the pride she felt watching Poitier, the first black man to win the best best actor Oscar, to the impact she hoped she could have on young women.

Winfrey also addressed the sexual misconduct scandal roiling Hollywood and beyond, telling those watching "speaking your truth is the most powerful tool you all have."

Reese Witherspoon introduced Winfrey and described their friendship, forged over long sessions in a makeup trailer while filming A Wrinkle in Time.

Witherspoon said sitting in the room with Oprah was like taking the best business classes, and her hugs could end wars.

WATCH THE SPEECH HERE:

“I want all of the girls watching here now to know, that a new day is on the horizon.” @Oprah accepts the 2018 Cecil B. de Mille award. #GoldenGlobes pic.twitter.com/hbquC1GBjm
— Golden Globe Awards (@goldenglobes) January 8, 2018