EMBL-GSK Postdoctoral Fellow in Cryo-EM of Chromatin Complexes : Heidelberg

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Job Description

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked scientific research organisations in the world. The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Barcelona (Spain), Grenoble (France), Hamburg (Germany), Hinxton near Cambridge (UK), Rome (Italy). EMBL has a strong focus on cutting edge technologies. Major activities are in the areas of imaging and structural methods (high resolution light microscopy, cryo-EM, tissue imaging), genomics (quantitative genetics, chromatin and RNA biology, microbiome), proteomics, metabolomics, biosensors and microfluidics, embryonic development).

We are seeking to recruit an outstanding postdoctoral fellow to explore the use of cryo-EM to study small-molecule ligand-bound structures of chromatin complexes. In particular, we are planning to apply recent methodological developments (phase plate, automated EM grid dispenser etc.) in studying epigenetic targets. Develop protocols in grid preparation and data acquisition that increase throughput and support lead optimization in drug discovery projects. Acquire high resolution data sets of ligand-bound chromatin complexes and other epigenetic targets thereby guiding ligand optimization and ultimately drug development.

The position is part of a collaboration between EMBL and GSK. The successful candidate will join the Christoph Müller group at the Structural and Computational Biology Unit at EMBL Heidelberg, but will also closely interact with our industry partner GlaxoSmithKline (GSK). The candidate will be part of the EMBL Postdoctoral Program with access to training, mentorship and career development opportunities. In addition they will also benefit from participation in the GSK post-doctoral program, formal mentorship and various trainings/seminar series in drug discovery. EMBL is a leading international research organization with a collaborative and interdisciplinary atmosphere (see www.embl.de). The cryo-EM facilities at EMBL are outstanding and include two FEI Titan Krios, one Talos Arctica and one Polara microscope equipped with state-of-the-art direct electron detectors. About GSK: GSK, a science-led global healthcare company, brings to collaborations a vast knowledge around target validation and cutting-edge Drug Discovery technologies (e.g. compound libraries, screening platforms, chemoinformatics, structural biology, chemical biology/chemoproteomics). GSK acquired the EMBL spinoff Cellzome in 2012 and thus maintains a presence on the EMBL campus.

Qualifications and Experience

The successful candidate holds a Ph.D. in structural biology or biochemistry. The project is particularly suitable for a postdoctoral fellow with solid previous experience in cryo-EM who is interested in utilizing and further developing cryo-EM methodology for studying epigenetic targets and visualizing small molecule ligands in the drug discovery process. The position requires exceptional motivation and commitment, the ability to work independently as well as in a team and excellent technical, organizational and management skills. A contract of 2 years, with an optional 3rd year, will be offered to the successful candidate.

Application Instructions

Please apply online through www.embl.org/jobs

Additional Information

Further details of the project can be directly obtained from Christoph W. Müller (cmueller@embl.de).   EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation with a very collegial and family friendly working environment. The remuneration package comprise a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation and installation, including your family.

Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.