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Manchester City striker Gabriel Jesus is out after suffering a knee injury in the 0-0 draw against Crystal Palace.
Kevin de Bruyne was also forced off after a heavy tackle and is a doubt to be available tonight.
John Stones and Sergio Aguero are likely to start but David Silva is expected to be absent for personal reasons once again.
Watford captain Troy Deeney will complete a four-match suspension and will not feature against the Premier League leaders.
Marco Silva is expected to choose from the same players he had available against Swansea.
Pep Guardiola, asked about his Manchester City side ending the league season undefeated said: "That is not going to happen. I am not thinking to be unbeaten.
"Maybe Arsene [Wenger] is worried about that but I tell him many times that 2004 run [when Arsenal avoided defeat throughout 2003-04] is for him.
"Today is completely different to 2004. [There] are now more strong teams, a lot of competitions, a lot of games. That is not going to happen."
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