The Jaguars will be without two of their top receivers for today’s meeting against the 49ers at Levi’s Stadium.

Both Marquise Lee (ankle) and Allen Hurns (ankle) are inactive. Lee has team-highs of 56 catches and 702 yards, while Hurns is second in receptions (46) and third in yards (446).

Without the duo in the lineup, quarterback Blake Bortles will look to a wide receiver corps now led by rookies Keelan Cole (32, 607) and rookie Dede Westbrook (22, 256). Last week, Cole had 7 catches, 186 yards and a touchdown in a 45-7 win over the Texans.

Meanwhile, for the 49ers, tight end Garrett Celek (knee, rib), is active after he was listed as questionable. Cornerback Greg Mabin (calf), who was doubtful, is inactive.

The 49ers’ other inactives are defensive end Aaron Lynch, wide receiver Max McCafrrey, linebacker Pita Taumoepenu, safety Antone Exum and defensive linemen Leger Douzble and D.J. Jones.

Lynch is inactive after playing the past two weeks. He had four tackles and a fumble recovery in a win at Houston on Dec. 10. He didn’t play a defensive snap in last week’s win against Tennessee.

Twitter: @Eric_Branch