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Development of wildtype and knockout brain endothelial reporter cells
05:05 EST 21 Dec 2017 | NIH
IC:
NCI
NIH Ref. No.:
E-079-2015
Advantages:
- TEM5 is selectively upregulated in cerebrovasculature of tumors
- TEM5 inhibitors have less potential for causing side effects compared to other Wnt signaling inhibitors
Applications:
- High throughput screen for TEM5 (GPR12) inhibitors
Development Status:
Discovery (Lead Identification)
Updated On:
Dec 20, 2017
Provider Classifications:
Publications:
patent field-type-field-collection field-label-hidden">
Licensing Contacts:
Lead Inventor:
Inventor IC:
NCI
Inventor Lab URL:
http://ccr.cancer.gov/brad-st-croix
Inv Is lead:
LPM Phone:
240-276-5515
LPM Email:
John.Hewes@nih.gov
DTDT Classification:
Research Materials
DTDT Description:
Research Materials
Publication Link:
http://www.ncbi.nlm.nih.gov/pubmed/25558062
https://www.ncbi.nlm.nih.gov/pubmed/21421844
Publication Caption:
PMID:25558062
PMID:21421844
Publication Title:
Posokhova E et al.
Cullen M et al.
Collaboration Sought:
Yes
Institute or Center:
Collaboration Opportunity:
Licensing and research collaboration
Inventor First Name:
Brad
Inventor Last Name:
St. Croix
Original Article: Development of wildtype and knockout brain endothelial reporter cells
