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Nanoparticles for the targeted treatment of infected cells
05:03 EST 21 Dec 2017 | NIH
IC:
NCI
NIH Ref. No.:
E-039-2012
Advantages:
- Novel way for multiple functionality delivery and activation
- Enhanced chemical stability and pharmacokinetics due to the average size of nanoparticles exceeding 10nm
- Increased specificity for selecting cells of interest using more than one target gene
Applications:
- Therapeutic siRNA for cancer and viral infections
- Diagnostic to visualize cancerous or virus-infected cells or track delivery and effectiveness of siRNA treatment.
- Research tool to study cancer, viral infection, or other diseases
Development Status:
Pre-clinical (in vivo)
Updated On:
Dec 20, 2017
Provider Classifications:
Publications:
Patent Application:
61/561,257
PCT/US2012/06594
Patent Number:
9,631,192
6,093,775
2,780,455
Licensing Contacts:
Lead Inventor:
Inventor IC:
NCI
Inventor Lab URL:
https://ccr.cancer.gov/Gene-Regulation-and-Chromosome-Biology-Laboratory/bruce-a-shapiro
Inv Is lead:
LPM Phone:
240-276-5515
LPM Email:
John.Hewes@nih.gov
DTDT Classification:
Therapeutics
DTDT Description:
Therapeutics
Pat Filing Date:
2011-11-17T00:00:00
2012-11-19T00:00:00
Patent Issue Date:
2017-04-25T00:00:00
2017-02-05T00:00:00
2017-07-05T00:00:00
Publication Link:
http://www.ncbi.nlm.nih.gov/pubmed/23016824
http://www.ncbi.nlm.nih.gov/pubmed/21229999
http://www.ncbi.nlm.nih.gov/pubmed/22134126
Publication Caption:
PMID 23016824
PMID 21229999
PMID 22134126
Publication Title:
Afonin KA et al.
Grabow W et al.
Afonin KA et al.
Collaboration Sought:
Yes
Institute or Center:
Collaboration Opportunity:
Licensing and research collaboration
Related Invention:
E-038-2012
Inventor First Name:
Bruce
Inventor Last Name:
Shapiro
Original Article: Nanoparticles for the targeted treatment of infected cells
