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Motorists travelling to spend the festive period with loved ones have been warned to expect long delays.
The worst jams today will be on the M6 southbound between Merseyside and Staffordshire.
Hold-ups are predicted to reach four hours and 21 minutes, according to traffic information supplier Inrix.
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“We strongly urge drivers planning long journeys to avoid this day”
Rod Dennis
Other hotspots include the M3 westbound in Surrey and the M74 southbound from Glasgow to Hamilton.
Journeys are set to be even slower tomorrow as the last of the year's commuter traffic clashes with the Christmas getaway, amid a rail strike.
The RAC expects traffic to peak between 4pm and 8pm on Friday.
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Inrix chief economist Dr Graham Cookson said: "Drivers would be well advised to take alternative routes or avoid driving during peak times altogether."
RAC traffic spokesman Rod Dennis added: "Things tend to get worse on the last working day before Christmas, with 'Frantic Friday' this year falling on the 22 December.
"We strongly urge drivers planning long journeys to avoid this day if they possibly can."
The RAC estimates that 11.5 million leisure trips will be made by car between December 17 and Christmas Eve.
But this will be eclipsed by the 17.5 million between Christmas Day and New Year's Day.
People are expected to be taking advantage of post-Christmas sales at shops.
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Almost 400 miles of roadworks will be lifted by Highways England to ease journeys.
The "roadworks embargo" will be in place on motorways and major A roads from 6am on Friday until January 2.
A strike by rail workers on Virgin Trains tomorrow will see a reduced timetable in operation, which could force more people to travel on already congested roads.