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New Mechanism for Cisplatin Hearing Loss Uncovered

05:33 EST 20 Dec 2017 | Genetic Engineering News

Side effects from chemotherapy can range from the mildly acute, such as nausea, to severe chronic disorders, like hearing loss. Understanding and potentially mitigating side effects are of paramount concern for clinicians, drug manufacturers, and patients alike. With that in mind, a team of investigators at the National Institute on Deafness and other Communications Disorders (NIDCD)—part of the National Institutes of Health (NIH)—has found a new way to explain the hearing loss caused by cisplatin, a powerful drug used to treat many forms of cancer. Findings from the new study were published recently in Nature Communications in an article entitled “ Cisplatin Is Retained in the Cochlea Indefinitely following Chemotherapy .” "Hearing loss can have a major impact on a person's life, as many adults with hearing loss struggle with social isolation and depression, among other conditions,” explained James Battey, Jr., M.D., Ph.D., director of NIDCD. " Children ...

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