Post Title: Postdoctoral Research Fellow in Structure-Guided Drug Discovery
SBU/Department: Life and Medical Sciences
Salary: UH7 £32,548 to 38,833 (pro rata) pa depending on skills and experience
Grade UH7
FTE: Full time position working 37 hours per week 1.0 FTE
Duration of Contract: Fixed Term to 31st December 2019
Applications are invited for a postdoctoral research fellow to join an exciting joint initiative between the University of Hertfordshire and the University of Cambridge, funded by the Hertfordshire Science Partnership Therapy Accelerator‡ scheme. The successful candidate will be part of a multidisciplinary team exploring novel inhibitors of a cancer drug target protein. The position offers access to the state of the art laboratory facilities at the University of Cambridge and the University of Hertfordshire, plus the opportunity to work at the dynamic industry/academia interface of the Stevenage BioScience Catalyst campus (http://www.stevenagecatalyst.com/).
The successful applicant will work with Dr Marko Hyvönen (Cambridge, http://hyvonen.bioc.cam.ac.uk/), Dr Sharon Rossiter (Hertfordshire) and Dr Stewart Kirton (Hertfordshire), to develop and optimise biophysical methods for high-throughput screening of inhibitors, measurement of inhibitor-protein interactions, crystallographic elucidation of ligand-protein complexes and fragment-based approaches to discovering novel inhibitor scaffolds as a potential therapy for pancreatic cancer.
Applicants should possess (or about to obtain) a doctorate in biochemistry, chemistry, structural biology or a closely related subject.
Experience in the following techniques is essential: molecular cloning, protein expression, purification and characterisation, biophysical analysis of protein-ligand interactions and protein crystallography.
Additional experience in structure-guided and/or fragment-based drug discovery, molecular modelling or chemoinformatics would be an advantage. The successful candidate should have good organisational skills, be independent, task-oriented and focused, and be used to working to tight deadlines and meeting project milestones.
‡ The Hertfordshire Science Partnership (HSP) is the University of Hertfordshire’s innovative solution to growing research and innovation in Hertfordshire’s life sciences industries. The Partnership was born out of initial funding from the Hertfordshire Local Enterprise Partnership to establish the Hertfordshire Knowledge Innovation Centre for Science. This funding has been augmented by European Regional Development Funding to support SMEs specifically but not exclusively as programme partners and this funding is now matched by staff time and facilities in the newly opened state-of-the-art science laboratories here at the University of Hertfordshire. As part of this initiative, the Therapy Accelerator was an open competition that provided funding to successful projects and that aims to support basic research and development in therapeutic and diagnostic sciences in Hertfordshire.
Contact Details/Informal Enquiries: Contact Dr Sharon Rossiter, Principal Lecturer, at s.rossiter@herts.ac.uk
Closing Date: 14th January 2018
Reference Number: 015756
The University offers a range of benefits including a pension scheme, professional development, family friendly policies, child care vouchers, a fee waiver of 50% for all children of staff under the age of 21 at the start of the course, discounted memberships at the Hertfordshire Sports Village and generous annual leave.
Apply online at http://www.herts.ac.uk/contact-us/jobs-and-vacancies
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