Outgoing White House aide Omarosa Manigault Newman took issue with President Trump's endorsement of Alabama Senate candidate Roy Moore.

Multiple reports indicate it was the latest in a string of disagreements she had with her longtime friend in the White House — and would be the last as she either resigned or was fired Wednesday.

A friend of Manigault Newman, businessman Armstrong Williams, suggested her dislike of Moore stemmed from her "being a woman," as Moore faced several accusations of inappropriate behavior with women then they were in their teens and he was in his 30s.

“As recently as last week she told me about her concerns about the president endorsing Roy Moore. It bothered her, being a woman,” Williams told the Washington Post.

Moore, who lost the Senate special election in Alabama on Tuesday, also had made statements that were insensitive to African Americans.

The timing of Manigault Newman's ouster is somewhat suggestive as it coincided with the result of the Alabama contest. An official White House statement said she "resigned yesterday to pursue other opportunities" and would officially part ways with the White House in January.

Meanwhile, reporting indicated that she was outright fired after she threw a tantrum Tuesday night after chief of staff John Kelly refused her an audience with Trump.

Both the Post and TMZ cited sources saying Manigault Newman, who has been close to Trump since appearing in the first season of "The Apprentice" in 2004, had long chaffed at Trump's statements and actions involving matters of race.

Manigault Newman was in charge of outreach to the African American community.

Manigault Newman disliked that Trump said in August that there was blame on "both sides" of the violence that resulted between white supremacist protesters and counter-protesters in Charlottesville, Va., the Post noted.

TMZ also pointed out that she did not approve of Trump's war of words with prominent African American Democrat, Rep. Frederica Wilson of Florida, over his condolence call with an African American Gold Star widow.

Further clarification on the circumstances of her White House departure could come as soon as Thursday morning. Manigault Newman is slated to have her first post-White House interview on ABC's "Good Morning America" tomorrow.