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Manchester United made it a club record-equalling 40 home games unbeaten in all competitions with the 2-1 midweek victory against CSKA Moscow, securing Champions League top spot in the process.
However, taking the record outright looks a tough ask with City rolling into town without a loss in the Premier League to their name.
No team has ever enjoyed a better start to a top-flight campaign and Pep Guardiola's men already boast an eight-point cushion at the summit. Second-placed United cannot afford to let it get any bigger.
City have been required to dig deep in recent Premier League games and came a cropper for the first time in Ukraine as Guardiola's rotated side went down 2-1 to Shakhtar Donetsk on Wednesday evening.
Given they were already guaranteed top spot in their Champions League group, it had no real impact aside from the fact their cloak of invincibility fell.
That will give United hope and their travel is hardly going to help preparation.
Manchester United vs Manchester City line-ups
Man Utd: De Gea, Valencia, Smalling, Rojo, Young, Ander Herrera, Matic, Martial, Lingard, Rashford, Lukaku
Subs: Lindelof, Jones, Mata, Ibrahimovic, Romero, Shaw, McTominay
Man City: Ederson, Walker, Otamendi, Kompany, Delph, De Bruyne, Fernandinho, Silva, Sterling, Gabriel Jesus, Sane
Subs: Bravo, Danilo, Gundogan, Aguero, Mangala, Bernardo Silva, Alexander Zinchenko
Referee: Michael Oliver (Northumberland)
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