The Blues boss is without Danny Drinkwater, who is absent with an illness.
David Luiz is also sidelined with a knee injury.
As for West Ham, David Moyes has axed Joe Hart, with Adrian starting in his place.
The Spain ace impressed against Manchester City last weekend and Moyes has rewarded his goalkeeper.
Mark Noble also returns to the starting XI for the Hammers.
Speaking ahead of the clash, Conte said: "This league is very tough, especially because there is a team [Manchester City] that is on an extraordinary path.
"West Ham has a good squad with good players. To see them in this position is a bit strange."
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David Luiz next club odds
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West Ham: Adrian, Zabaleta, Reid, Ogbonna, Cresswell, Noble, Obiang, Arnautovic, Lanzini, Masuaku, Antonio.
Subs: Hart, Rice, Fernandes, Ayew, Carroll, Sakho, Hernandez.
Chelsea: Courtois; Azpilicueta, Christensen, Cahill (c); Zappacosta, Bakayoko, Kante, Fabregas, Alonso; Hazard, Morata.
Subs: Caballero, Rudiger, Ampadu, Moses, Willian, Pedro, Batshuayi.