The UK's national observatory has issued an amber wind warning for northern Scotland and yellow warnings for southern Scotland and northern England, which will spread south on Friday and continue into Saturday.
Caroline is the third named storm of the 2017-2018 winter season, after Aileen in September and Brian in October.
Here's what to expect:
:: Gusts of 70 to 80mph will be widespread across northern Scotland when the weather front hits at about 6am on Thursday.
:: UK weather: The latest Sky News forecast
:: Wind speeds could reach 90mph in exposed areas.
:: The Met Office has warned "flying debris is likely and could lead to injuries or danger to life".
:: Damage to buildings is possible, especially tiles blowing off roofs.
:: Longer travel times are extremely likely as many roads may be closed.
:: Storm Caroline: Met Office warns of potential risk to life as UK set to be battered by 90mph winds
:: Rail, air and ferry services are likely to be cancelled.
:: There is a "good chance" power cuts will occur.
:: Temperatures will plunge to -1C in the West by Saturday.
:: Large waves are expected and beach material, including pollution, may be thrown on to coastal roads, seafronts and properties.
:: From the early hours of Friday the majority of the UK will be affected by snow and ice, with 10-20cm of snow falling in places - mainly northern Scotland, Northern Ireland, north Wales and the northwest Midlands.
:: The Met Office has warned some vehicles and passengers could be stranded due to possible travel delays on roads across most of the UK from Friday.
:: Britons are being told to prepare for the storm by clearing any potential debris, including from gutters and loose tiles, as well as securing any outbuildings.