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While this is a dead rubber for Tottenham, who have already secured top spot in the group, Apoel can still secure a place in the Europa League given they sit level on points with Dortmund, who finish away to Real Madrid.
Apoel drew both of their games against Dortmund 1-1, meaning head-to-head would defer to goal difference if they end up on the same total.
Apoel's goal difference is currently -12 while Dortmund have -5, which means Apoel would either have to engineer a seven-goal swing or, more likely, better Dortmund's result at the Santiago Bernabeu.
Apoel lost 3-0 at home to Spurs in September.
Tottenham sealed qualification and first place in Group H by beating Borussia Dortmund last month, this seemed the perfect game to rest key players and prioritise the race for the Premier League title.
But since their 2-1 win in Germany, Spurs have fallen 18 points behind Manchester City following two draws and a defeat in the league and there is now a case for placing greater importance on getting back to winning ways.
Key players will be left out but manager Mauricio Pochettino is still expected to field an experienced team. He will know the value of confidence and momentum.