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PARP inhibitor may be effective against some TNBC lacking BRCA mutations
20:00 EDT 31 Oct 2017 | AAAS
(American Association for Cancer Research) The investigational PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) that had BRCA mutations and also those that did not have BRCA mutations but had other alterations in DNA damage-repair pathways.
Original Article: PARP inhibitor may be effective against some TNBC lacking BRCA mutations
