New DNA Replication Model May Open Therapeutic Door
Scientists say their work on a critical step in DNA replication will provide new insights into a fundamental process of life and driver of many different diseases, including cancer. They report the results of their study (“Cryo-EM Structure of Mcm2-7 Double Hexamer on DNA Suggests a Lagging-Strand DNA Extrusion Model") in PNAS . "Previous studies have described how enzymes assemble and gather around DNA to prepare it for replication. Here, we describe what these enzymes do to DNA once they are in place," says Huilin Li, Ph.D., a professor in the Center for Epigenetics at the Van Andel Research Institute and senior author of the paper. DNA replication is a tightly choreographed process that copies the genetic code, allowing its instructions to be passed on from one generation of cells to the next. In diseases like cancer, these mechanisms can fail, leading to uncontrolled or faulty replication with ...
Original Article: New DNA Replication Model May Open Therapeutic Door
