Alex Iwobi’s goal saw Nigeria become the first African team to qualify for next year’s World Cup in Russia, while Ghana was eliminated in the qualifiers.
A 73rd-minute strike by Arsenal forward Iwobi handed the Super Eagles a 1-0 success over Zambia in Uyo, ensuring top spot in Group B with a game to spare.
Nigeria now has 13 points with second-placed Zambia on seven. Cameroon is on six points after defeating Algeria 2-0.
Costa Rica joined Mexico in advancing from the North and Central America and Caribbean (CONCACAF) region with three final matches to play on Tuesday.
Three CONCACAF teams advance directly to the finals in Russia with a fourth to play off against either Syria or Australia for a berth.